Nucleotide excision repair in humans

Nucleotide Excision Repair from Bacteria to Humans: Structure–Function Studies

T.M. Penning (ed.), Chemical Carcinogenesis, Current Cancer Research, DOI 10.1007/978-1-61737-995-6_13, © Springer Science+Business Media, LLC 2011 Abstract This chapter describes our present knowledge of nucleotide excision repair (NER) in both prokaryotic and eukaryotic organisms. NER is a generalized repair system capable of removing a wide range of DNA lesions differing in their shape and c...

Prokaryotic nucleotide excision repair.

Nucleotide excision repair (NER) has allowed bacteria to flourish in many different niches around the globe that inflict harsh environmental damage to their genetic material. NER is remarkable because of its diverse substrate repertoire, which differs greatly in chemical composition and structure. Recent advances in structural biology and single-molecule studies have given great insight into th...

SnapShot: Nucleotide Excision Repair

Nucleotide Excision Repair and Cancer

Cancer ranks as one of the most frequent causes of death worldwide and in Western society it is competing with cardiovascular disease as the number one killer. This high frequency in Western countries can be attributed to lifestyle and environmental factors, only 5-10% of all cancers are directly due to heredity. Common environmental factors leading to cancer include: tobacco (25-30%), diet and...

Base flipping in nucleotide excision repair.

UvrB, the ultimate damage-binding protein in bacterial nucleotide excision repair is capable of binding a vast array of structurally unrelated lesions. A beta-hairpin structure in the protein plays an important role in damage-specific binding. In this paper we have monitored DNA conformational alterations in the UvrB-DNA complex, using the fluorescent adenine analogue 2-aminopurine. We show tha...